Difference between DEXAMPHETAMINE & METHYLPHENIDATE in ADHD | ADDERALL | RITALIN | DR REGE EXPLAINS

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DEXAMPHETAMINE and METHYLPHENIDATE are medications used to treat Attention-deficit Hyperactivity Disorder (ADHD).
Dr Rege, Consultant Psychoiatrist, explains the differences.
#adhd #adderall #ritalin #vyvanse #dexamphetamine #methylphenidate #amfetamine

Methylphenidate (MPH)
Mechanism of Action:
Non-competitively, Methylphenidate blocks the reuptake dopamine/noradrenaline into terminals by blocking dopamine transporter and noradrenalinetransporter (NAT), increasing dopamine levels in the synaptic cortex.

An l-isomer as well as a d.isomer are available for Amphetamine.
The active isomer is the d-isomer.
Mechanisms of Action :
1. Competing with noradrenaline and dopamine at NAT, competitive inhibitor at DAT
2. VMAT
Competitive inhibitor3. Reversal of DAT.

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